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The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure.
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Key regulator of entry into cell division that acts as a tumor suppressor Acts as a transcription repressor of E2F1 target genes The underphosphorylated active form of RB1 interacts with E2F1 and represses its transcription
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Boster Bio Anti-Phospho-Rb (Ser780) RB1 Antibody (Catalog # P00039). Tested in WB, IHC, IF applications. This antibody reacts with Human, Mouse, Rat.
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Retinoblastoma (RB) is an embryonic malignant neoplasm of retinal origin. It almost always presents in early childhood and is often bilateral. Spontaneous regression ('cure') occurs in some cases.
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Phospho-Rb-S780 Antibody; Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
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